Checkpoint Control Kinase Degraders

Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed. Checkpoint control kinases function to halt the cell cycle at these critical points. Examples of checkpoint control kinases include ATM, ATR, DNA-PK, Chk1, Chk2, Wee1 and mTOR.

For a cell to progress through the cycle and ...