3 results for "ATM and ATR Kinase Inhibitors" in Products
ATM and ATR Kinase Inhibitors
ATM (Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related) are closely related kinases that are activated by DNA damage. These serine-threonine protein kinases are part of the phosphatidylinositol 3' kinase-like kinase (PIKK) family.
Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key proteins. Once activated, the checkpoint leads to cell cycle arrest and either DNA repair or apoptosis. ATM is activated by double stranded breaks and phosphorylates Chk2, whilst ATR is activated by single strand breaks and phosphorylates Chk1.
Potent and selective ATM kinase inhibitor
| Chemical Name: | 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one |
| Purity: | ≥98% |
Potent and selective ATR kinase inhibitor; antitumor
| Chemical Name: | 4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole |
| Purity: | ≥98% |
Potent and selective ATM kinase inhibitor; orally bioavailable
| Chemical Name: | 7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide |
| Purity: | ≥98% |
