Degrader Building Blocks

Tocris provides Building Blocks to support Degrader research and development. Degraders (e.g. PROTAC^® molecules, SNIPERs etc) are heterobifunctional small molecules that are modular in design, comprising binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. Our Degrader components have functional handles for easy conjugation to ligands/linkers of interest. The range includes the most effective and commonly used E3 ubiquitin ligase ligands, functionalized at ...