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8 results for "DNA Topoisomerase Inhibitors" in 产品
DNA Topoisomerase Inhibitors
Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as overwinding (positive supercoiling), knots and tangles are resolved by topoisomerases by catalyzing the breaking of one or two strands of DNA.
Topoisomerase type I enzymes cut just one strand of the DNA double helix, and therefore relax supercoiling of the DNA. Four genes encode Type I topoisomerases, which ...
| Alternate Names: | Adriamycin,NSC 123127 |
| Chemical Name: | 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride |
| Purity: | ≥98% |
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| Chemical Name: | (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Purity: | ≥98% |
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| Chemical Name: | [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one |
| Purity: | ≥98% |
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| Alternate Names: | 7-Ethyl-10-hydroxycamptothecin |
| Chemical Name: | (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione |
| Purity: | ≥98% |
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| Chemical Name: | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
| Purity: | ≥98% |
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| Alternate Names: | Irinotecan,Camptothecin 11 |
| Chemical Name: | (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride |
| Purity: | ≥98% |
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| Alternate Names: | ICRF-187 |
| Chemical Name: | 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride |
| Purity: | ≥98% |
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| Alternate Names: | CP 99219 |
| Chemical Name: | 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate |
| Purity: | ≥98% |
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