GSK-3 Inhibitors

The serine/threonine kinase Glycogen synthase kinase 3 (GSK-3) has two isoforms (α and β). GSK-3 is a key enzyme in glycogen metabolism, as well as cell division, proliferation, motility and survival. The enzyme plays a role in a number of pathological conditions, including cancer, diabetes and neurological diseases.

GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although ...