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9 results for "MEK1 Small Molecules and Peptides" in 产品
MEK1 Small Molecules and Peptides
MEK1 and MEK2, also known as MAP2K1 and MAP2K2, are activated in response to mitogenic stimuli. Activation occurs through dual phosphorylation at S218/S222 of MEK1 and S222/S226 of MEK2 by several upstream MAP3Ks. Both MEK1 and MEK2 are dual-specificity protein kinases, phosphorylating and activating ERK1 and ERK2 at Thr and Tyr positions.
Potent, selective inhibitor of MEK1 and 2
| Chemical Name: | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
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Potent inhibitor of MEK1/2
| Alternate Names: | PD325901 |
| Chemical Name: | N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide |
| Purity: | ≥99% |
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MEK inhibitor
| Chemical Name: | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% |
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Selective inhibitor of MEK1 and MEK2; brain penetrant
| Chemical Name: | α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile |
| Purity: | ≥98% |
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Selective inhibitor of MEK1/2
| Chemical Name: | N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide |
| Purity: | ≥98% |
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Selective MEK inhibitor
| Alternate Names: | CI-1040 |
| Chemical Name: | 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide |
| Purity: | ≥98% |
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Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
| Alternate Names: | (-)-Arctigenin |
| Chemical Name: | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone |
| Purity: | ≥98% |
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MEK1 inhibitor
| Chemical Name: | N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine |
| Purity: | ≥98% |
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Potent and selective MEK inhibitor; orally bioavailable
| Chemical Name: | N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide |
| Purity: | ≥98% |
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