NTPDase Inhibitors

Ectonucleotidases (also known as NTPDases, Ecto-ATPases, ectonucleoside triphosphate diphosphohydrolase) are ectoenzymes that hydrolyze extracellular nucleotides. There are four major families of ectonucleotidases: CD39/NTPDases (ecto-nucleotide triphosphate diphosphohydrolases); ecto-nucleotide pyrophosphatase phosphodiesterases (E-NPPs); alkaline phosphatases; and ecto-5'-nucleotidases/CD73.

NTPDases are constitutively expressed in many tissues and can be differentiated on the basis of ...