Ret Proteome Profiler Antibody Arrays

The GDNF family members (GDNF, neurturin, artemin, and persephin) signal through multicomponent receptors that consist of the Ret receptor tyrosine kinase and one of four glycosyl-phosphatidylinositol (GPI)-linked ligand-binding subunits (GFR alpha-1-4). GFR alpha-1, -2, -3 and -4 are the preferred ligand-binding subunits for GDNF, neurturin, artemin, and persephin, respectively. The Ret tyrosine-kinase receptor is encoded by the c-ret proto-oncogene. Human and mouse Ret share 83% amino acid sequence homology.