1-Azakenpaullone

Key Product Details

Product Description

1-Azakenpaullone is a potent and selective inhibitor of glycogen synthase kinase 3 (GSK-3), with IC₅₀ = 18 nM. It displays selectivity index (SI) of 111 and 233 over CDK1 and CDK5, respectively.

1-Azakenpaullone stimulates growth and replication of β-cells in vitro (rat islets) and alleviates glucolipotoxicity in INS-1 β-cells. It displays mitogenic effects on rat β-cells comparable with those of incretin hormone GIP.

In combination with TTNPB (Cat. No. 0761) and WS 6 (Cat. No. 7791), 1-Azakenpaullone can be part of a chemical cocktail used for induction and long-term maintainance in vitro of totipotent stem cells (TotiSCs) from mouse pluripotent stem cells (PSCs).

Product Specifications for 1-Azakenpaullone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 1-Azakenpaullone

The following data is based on the product molecular weight 328.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.24 mL	30.47 mL
5 mM	0.61 mL	3.05 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.05 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Mussmann Inhibition of GSK3 promotes replication and survival of pancreatic beta cells. J.Biol.Chem. 2007 PMID: 17242403
• Hu Induction of mouse totipotent stem cells by a defined chemical cocktail. Nature 2023 PMID: 35728625
• Kunick 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β. Bioorg.Med.Chem.Lett. 2004 PMID: 14698171

Product Documents for 1-Azakenpaullone