Biological ActivityIndoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
Rytelewski, Mateusz, Meilleur, Courtney, Yekta, Maryam A, Szabo, Peter A, Garg, Nitan, Schell, Todd D, Jevnikar, Anthony, Sharif, Shayan, Singh, Bhagirat, Haeryfar, S M Mans
PLoS ONE, 2014;9(2):e90439.
Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
Nakamura et al.
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