Catalog # Availability Size / Price Qty
1-Methyl-D-tryptophan | CAS No. 110117-83-4 | Indoleamine 2,3 Dioxygenase Inhibitors
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Description: Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names: 1MT

Purity: ≥97%

Product Details
Citations (1)
Supplemental Products

Biological Activity

1-Methyl-D-tryptophan is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data

Soluble to 5 mM in water with gentle warming
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
    Nakamura et al.
    Int.J.Hematol., 2015;102:327
  2. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
    Rytelewski, Mateusz, Meilleur, Courtney, Yekta, Maryam A, Szabo, Peter A, Garg, Nitan, Schell, Todd D, Jevnikar, Anthony, Sharif, Shayan, Singh, Bhagirat, Haeryfar, S M Mans
    PLoS ONE, 2014-02-28;9(2):e90439.

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Citation for 1-Methyl-D-tryptophan

The citations listed below are publications that use Tocris products. Selected citations for 1-Methyl-D-tryptophan include:

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