1-Methyl-D-tryptophan

Catalog # Availability Size / Price Qty
5698/50
Cat.No. 5698 - 1-Methyl-D-tryptophan | C12H14N2O2 | CAS No. 110117-83-4
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Description: Indoleamine 2,3-dioxygenase (IDO) inhibitor
Alternative Names: 1MT

Purity: ≥97%

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Biological Activity

Indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.

Technical Data

M.Wt:
218.25
Formula:
C12H14N2O2
Solubility:
Soluble to 5 mM in water with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
110117-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase.
    Rytelewski, Mateusz, Meilleur, Courtney, Yekta, Maryam A, Szabo, Peter A, Garg, Nitan, Schell, Todd D, Jevnikar, Anthony, Sharif, Shayan, Singh, Bhagirat, Haeryfar, S M Mans
    PLoS ONE, 2014;9(2):e90439.
  2. Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice.
    Nakamura et al.
    Int.J.Hematol., 2015;102:327

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