1400W dihydrochloride

Catalog # Availability Size / Price Qty
1415/10
1415/50
1400W dihydrochloride | CAS No. 214358-33-5 | iNOS Inhibitors
1 Image
Description: Potent, highly selective iNOS inhibitor

Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride

Purity: ≥99%

Product Details
Citations (9)
Reviews (3)

Biological Activity

1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.

Technical Data

M.Wt:
250.17
Formula:
C10H15N3.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
214358-33-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for 1400W dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 1400W dihydrochloride include:

9 Citations: Showing 1 - 9

  1. Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation.
    Authors: M?ller Et al.
    Front Immunol  2018;9:2520
  2. Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model
    Authors: Staunton Et al.
    Exp Physiol  2018;103:535
  3. Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model.
    Authors: Kuen Et al.
    PLoS One  2017;12:e0182039
  4. Selective activation of microglia facilitates synaptic strength.
    Authors: Clark Et al.
    RNA  2015;35:4552
  5. Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
    Authors: Gross Et al.
    J Mol Cell Cardiol  2013;59:20
  6. Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents.
    Authors: Gresa-Arribas Et al.
    PLoS One  2012;7:e45227
  7. Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.
    Authors: Al-Shalmani Et al.
    Br J Pharmacol  2011;162:1485
  8. Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.
    Authors: Tsuda Et al.
    J Cell Mol Med  2009;13:3251
  9. Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature.
    Authors: Ashrafpour Et al.
    Am J Physiol Heart Circ Physiol  2004;286:H946

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 1400W dihydrochloride

Average Rating: 5 (Based on 3 Reviews)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used 1400W dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Inhibition of iNOS by 1400W
By Anonymous on 04/03/2021
Application: Species: Mouse

Macrophages were treated with LPS (10 ng/mL) and IFN-y (20 ng/mL) for 24h in the presence of 1400W (100 uM)


1400W inhibits iNOS expression induced by LPS
By Anonymous on 05/16/2019
Application: Species: Mouse

RAW macrophages were treated with 200 ng/ml LPS alone or after pre-treatment with 1 μM 1400W (30 min pre-incubation) for 8 h to follow iNOS expression using Western blot. LPS treatment elevated iNOS expression while 1400W pretreatment significantly blunted this effect.


iNOS inhibitor
By Anonymous on 07/28/2018
Application: Species: Mouse

Used as iNOS inhibitor for organ bath experiments with rat and mouse aorta


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.