Chemical Name: N-[[3-(Aminomethyl)phenyl]methyl]-ethanimidamide dihydrochloride
Biological Activity1400W dihydrochloride is a slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd = 7 nM). Selective over nNOS and eNOS (Ki values are 2 and 50 μM respectively). Cell-permeable and active in vivo. Neuroprotective in epilepsy models and has analgesic effects in models of mechanical and heat hypersensitivity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo.
Garvey et al.
Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury.
Parmentier et al.
Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.
Thomsen et al.
Cancer Res., 1997;57:3300
Citations for 1400W dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 1400W dihydrochloride include:
9 Citations: Showing 1 - 9
Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation.
Authors: M?ller Et al.
Front Immunol 2018;9:2520
Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model
Authors: Staunton Et al.
Exp Physiol 2018;103:535
Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model.
Authors: Kuen Et al.
PLoS One 2017;12:e0182039
Selective activation of microglia facilitates synaptic strength.
Authors: Clark Et al.
Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts.
Authors: Gross Et al.
J Mol Cell Cardiol 2013;59:20
Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents.
Authors: Gresa-Arribas Et al.
PLoS One 2012;7:e45227
Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery.
Authors: Al-Shalmani Et al.
Br J Pharmacol 2011;162:1485
Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.
Authors: Tsuda Et al.
J Cell Mol Med 2009;13:3251
Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature.
Authors: Ashrafpour Et al.
Am J Physiol Heart Circ Physiol 2004;286:H946
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