Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (Kd
= 7 nM). Selective over nNOS and eNOS (Ki
values are 2 and 50 μ
M respectively). Cell-permeable and active in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo.
Garvey et al.
Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury.
Parmentier et al.
Selective inhibition of inducible nitric oxide inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.
Thomsen et al.
Cancer Res., 1997;57:3300
The citations listed below are publications that use Tocris products. Selected citations for 1400W dihydrochloride include:
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