Human 17 beta-HSD1/HSD17B1 ELISA Kit (Colorimetric)

Novus Biologicals | Catalog # NBP2-60473

Novus Biologicals
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Key Product Details

Sample Type & Volume Required Per Well

Serum, Plasma, Cell Culture

Sensitivity

0.5 ng/ml (example only; lot dependent)

Assay Range

0.781 - 50 ng/ml (example only; lot dependent)
View all 17 beta-HSD1/HSD17B1 ELISA Kits »

Product Specifications

Assay Type

Sandwich ELISA

Kit Type

ELISA Kit (Colorimetric)

Species

Human

Description

This assay employs a quantitative enzyme immunoassay technique that measures the specified antigen in samples.

Precision

Intra-Assay Precision (Precision within an assay) CV% 4.90% (example only; lot dependent)

Inter-Assay Precision (Precision between assays) CV% 9.50% (example only; lot dependent)

Recovery for Human 17 beta-HSD1/HSD17B1 ELISA Kit (Colorimetric)

Recovery

97.00% (example only; lot dependent)

Scientific Data Images for Human 17 beta-HSD1/HSD17B1 ELISA Kit (Colorimetric)

ELISA: Human 17 beta-HSD1/HSD17B1 ELISA Kit (Colorimetric) [NBP2-60473]

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: 17 beta-HSD1/HSD17B1

The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)

Long Name

17 beta Hydroxysteroid Dehydrogenase 1

Alternate Names

17 betaHSD1, E2DH, EDH17B2, EDHB17, HSD17B1, SDR28C1

Gene Symbol

HSD17B1

Additional 17 beta-HSD1/HSD17B1 Products

Product Documents for Human 17 beta-HSD1/HSD17B1 ELISA Kit (Colorimetric)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Human 17 beta-HSD1/HSD17B1 ELISA Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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