Chemical Name: 1-Methyl-7-nitro-2H-3,1-benzoxazine-2,4(1H)-dione
Biological ActivityReagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in <70 seconds.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry.
Mortimer et al.
Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7).
Turner et al.
RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP).
Siegfried et al.
Detection of RNA-Protein interactions in living cells with SHAPE.
Smola et al.
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