Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate
Biological Activity1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.
Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
Feng & Stockwell et al.
PLoS. Biol., 2018;16:e2006203
Regulation of ferroptotic cancer cell death by GPX4.
Yang et al.
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
Yang et al.
Citation for 1S,3R-RSL3
The citations listed below are publications that use Tocris products. Selected citations for 1S,3R-RSL3 include:
1 Citation: Showing 1 - 1
Metadherin enhances vulnerability of cancer cells to ferroptosis.
Authors: Bi Et al.
Cell Death Dis 2019;10:682
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