Catalog # Availability Size / Price Qty
1S,3R-RSL3 | CAS No. 1219810-16-8 | Other Reductase Inhibitors
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Description: Inhibits glutathione peroxidase (GPX4); induces ferroptosis

Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate

Purity: ≥98%

Product Details
Citations (4)

Biological Activity

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Columbia University.

Background References

  1. Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
    Feng & Stockwell et al.
    PLoS. Biol., 2018;16:e2006203
  2. Regulation of ferroptotic cancer cell death by GPX4.
    Yang et al.
    Cell, 2014;156:317
  3. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
    Yang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2016;113:E4966

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Citations for 1S,3R-RSL3

The citations listed below are publications that use Tocris products. Selected citations for 1S,3R-RSL3 include:

4 Citations: Showing 1 - 4


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