1S,3R-RSL3

Key Product Details

Product Description

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.

Licensing Information

Sold with the permission of Columbia University.

Product Specifications for 1S,3R-RSL3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 1S,3R-RSL3

The following data is based on the product molecular weight 440.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.13 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Yang Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc.Natl.Acad.Sci.U.S.A. 2016 PMID: 27506793
• Feng & Stockwell Unsolved mysteries: How does lipid peroxidation cause ferroptosis? PLoS. Biol. 2018 PMID: 29795546
• Yang Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 PMID: 24439385

Product Documents for 1S,3R-RSL3