2,4-Diamino-6-hydroxypyrimidine

Name: 2,4-Diamino-6-hydroxypyrimidine
Brand: Tocris Bioscience
SKU: 0476

Tocris Bioscience | Catalog # 0476

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Product Documents

Inhibits tetrahydrobiopterin synthesis and thus NOS activity

Discontinued Product

0476 has been discontinued. View all Additional NOS Inhibitors products.

Technical Data
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Product Description
Product Specifications
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Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Inhibits tetrahydrobiopterin synthesis and thus NOS activity

View all Additional NOS Inhibitors »

Product Description

2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).

Product Specifications for 2,4-Diamino-6-hydroxypyrimidine

Molecular Weight

126.12

Formula

C₄H₆N₄O

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

CAS Number

56-06-4

PubChem ID

2944

InChI Key

SWELIMKTDYHAOY-UHFFFAOYSA-N

SMILES

NC1=NC(N)=NC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Charles Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence. Eur.J.Pharmacol. 2019 PMID: 30690003
Werner-Felmayer Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP. J.Biol.Chem. 1993 PMID: 7678411
Xie GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine. J.Biol.Chem. 1998 PMID: 9694862
Moore and Handy Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPs 1997 PMID: 9226999

Product Documents for 2,4-Diamino-6-hydroxypyrimidine

Certificate of Analysis

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Product Specific Notices for 2,4-Diamino-6-hydroxypyrimidine

For research use only

Related Research Areas

Oxidative Stress

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