2-BFI hydrochloride

Key Product Details

Product Description

2-BFI hydrochloride is a high affinity I₂ ligand (K_i = 9.8 nM). Putative I₂ agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

Product Specifications for 2-BFI hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 2-BFI hydrochloride

The following data is based on the product molecular weight 222.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.49 mL	22.45 mL	44.91 mL
5 mM	0.90 mL	4.49 mL	8.98 mL
10 mM	0.45 mL	2.25 mL	4.49 mL
50 mM	0.09 mL	0.45 mL	0.90 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• MacInnes and Duty Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 2004 PMID: 15545290
• Sanchez-Blasquez Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 2000 PMID: 10781010
• Alemany Labelling of I_2B-imidazoline receptors by [³H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9228188

Product Documents for 2-BFI hydrochloride