High affinity I2
= 9.8 nM). Putative I2
agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
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All Tocris products are intended for laboratory research use only.
Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes.
Alemany et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:39
Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway.
MacInnes and Dut
Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Sanchez-Blasquez et al.
The citations listed below are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:
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