Catalog Number: 0348
Chemical Name: 2-(2-Benzofuranyl)-2-imidazoline hydrochloride
Biological Activity
High affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes.
    Alemany et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:39
  2. Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway.
    MacInnes and Dut
    Br.J.Pharmacol., 2004;143:952
  3. Activation of I2-imidazoline receptors enhances supraspinal morphine analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
    Sanchez-Blasquez et al.
    Br.J.Pharmacol., 2000;130:146

The citations listed below are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:

Showing Results 1 - 1 of 1

  1. Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
    Authors: Kim Et al.
    Brain Res
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