Chemical Name: 2-(2-Benzofuranyl)-2-imidazoline hydrochloride
Biological ActivityHigh affinity I2 ligand (Ki = 9.8 nM). Putative I2 agonist; potentiates morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Labelling of I2B-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes.
Alemany et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:39
Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway.
MacInnes and Dut
Activation of I2-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
Sanchez-Blasquez et al.
Citation for 2-BFI hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 2-BFI hydrochloride include:
1 Citation: Showing 1 - 1
Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
Authors: Kim Et al.
Brain Res 2011;1384:110
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