Chemical Name: 2-Deoxy-D-arabino-hexose
Biological ActivityNon-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic.
Kang and Hwang
Life Sci., 2006;78:1392
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.
Maher et al.
Cancer Chemother.Pharmacol., 2004;53:116
A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
Ralser et al.
Citation for 2-Deoxy-D-glucose
The citations listed below are publications that use Tocris products. Selected citations for 2-Deoxy-D-glucose include:
1 Citation: Showing 1 - 1
Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop.
Authors: Lin Et al.
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2-DG (10mM) was used to inhibit the glycolytic pathway in MDA-MB-231 cell lines.
Used to inhibit glycolysis and influence activity of a lipid peroxidation enzyme. Good activity was observed at 5 mM with the majority of cell lines surviving. We found a few cancer cell lines where 5 uM was cytotoxic
Used in brain slices to block glycolysis. Effect observed on cells within minutes of bulk application, as expected.