Catalog # Availability Size / Price Qty
2-Deoxy-D-glucose | CAS No. 154-17-6 | Mitochondrial Hexokinase Substrates
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Description: Non-metabolizable glucose analog; hexokinase substrate

Chemical Name: 2-Deoxy-D-arabino-hexose

Product Details
Citations (2)
Reviews (3)

Biological Activity

2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic.
    Kang and Hwang
    Life Sci., 2006;78:1392
  2. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.
    Maher et al.
    Cancer Chemother.Pharmacol., 2004;53:116
  3. A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
    Ralser et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:17807

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Citations for 2-Deoxy-D-glucose

The citations listed below are publications that use Tocris products. Selected citations for 2-Deoxy-D-glucose include:

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Reviews for 2-Deoxy-D-glucose

Average Rating: 4.7 (Based on 3 Reviews)

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Good quality for in vitro study
By Anonymous on 03/07/2020
Application: Species: Human

2-DG (10mM) was used to inhibit the glycolytic pathway in MDA-MB-231 cell lines.

Blockade of glycolysis at 5 mM enhances lipid peroxidation
By Anonymous on 02/27/2020
Application: Species: Human

Used to inhibit glycolysis and influence activity of a lipid peroxidation enzyme. Good activity was observed at 5 mM with the majority of cell lines surviving. We found a few cancer cell lines where 5 uM was cytotoxic

Glycolysis block
By Anonymous on 01/31/2018
Application: Species: Mouse

Used in brain slices to block glycolysis. Effect observed on cells within minutes of bulk application, as expected.

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