Catalog Number: 4515
Chemical Name: 2-Deoxy-D-arabino-hexose
Biological Activity
Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic.
    Kang and Hwang
    Life Sci., 2006;78:1392
  2. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.
    Maher et al.
    Cancer Chemother.Pharmacol., 2004;53:116
  3. A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
    Ralser et al.
    Proc.Natl.Acad.Sci.USA, 2008;105:17807
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