Non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro
models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
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All Tocris products are intended for laboratory research use only.
2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic.
Kang and Hwang
Life Sci., 2006;78:1392
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.
Maher et al.
Cancer Chemother.Pharmacol., 2004;53:116
A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
Ralser et al.