Chemical Name: 2-Deoxy-D-arabino-hexose
Biological Activity2-Deoxy-D-glucose is a non-metabolizable glucose analog. Inhibits phosphorylation of glucose by hexokinase; causes depletion of cellular ATP. Also inhibits phosphoglucose isomerase (PGI) competitively. Causes cell cycle inhibition and cell death in in vitro models of hypoxia; blocks tumor cell growth in animal models. Also shown to induce the unfolded protein response (UPR).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
2-deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic.
Kang and Hwang
Life Sci., 2006;78:1392
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions.
Maher et al.
Cancer Chemother.Pharmacol., 2004;53:116
A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth.
Ralser et al.
Citations for 2-Deoxy-D-glucose
The citations listed below are publications that use Tocris products. Selected citations for 2-Deoxy-D-glucose include:
2 Citations: Showing 1 - 2
A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding.
Authors: Beas Et al.
Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop.
Authors: Lin Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for 2-Deoxy-D-glucose
Average Rating: 4.7 (Based on 3 Reviews)
Have you used 2-Deoxy-D-glucose?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
2-DG (10mM) was used to inhibit the glycolytic pathway in MDA-MB-231 cell lines.
Used to inhibit glycolysis and influence activity of a lipid peroxidation enzyme. Good activity was observed at 5 mM with the majority of cell lines surviving. We found a few cancer cell lines where 5 uM was cytotoxic
Used in brain slices to block glycolysis. Effect observed on cells within minutes of bulk application, as expected.