Non-calcemic vitamin D3
(Cat. No. 4156) analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro
and in vivo
. Exhibits similar effects to calcitriol
(Cat. No. 2551) in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro
in combination with all-trans
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All Tocris products are intended for laboratory research use only.
22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure.
Monier-Faugere et al.
Kidney Int., 1999;55:821
Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo.
Barroga et al.