Calcitriol

Key Product Details

Product Description

Calcitriol is an active metabolite of vitamin D₃ that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca²⁺ absorption and regulates bone Ca²⁺ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Product Specifications for Calcitriol

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Calcitriol

The following data is based on the product molecular weight 416.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.00 mL	60.00 mL	120.01 mL
1 mM	2.40 mL	12.00 mL	24.00 mL
2 mM	1.20 mL	6.00 mL	12.00 mL
10 mM	0.24 mL	1.20 mL	2.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

• Beer and Myrthue Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 2004 PMID: 15026558
• Nijenhuis The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 2006 PMID: 16873882
• Canalejo The in vitro effect of calci. on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 2000 PMID: 11004217

Product Documents for Calcitriol