Active metabolite of vitamin D3
that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+
absorption and regulates bone Ca2+
turnover. Exhibits antitumor activity; inhibits in vivo
and in vitro
cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis.
Canalejo et al.
Calcitriol in cancer treatment: from the lab to the clinic.
Beer and Myrthue
Mol.Cancer Ther., 2004;3:373
The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.
Nijenhuis et al.
FASEB J., 2006;20:1589
The citations listed below are publications that use Tocris products. Selected citations for Calcitriol include:
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