Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
Biological ActivityActive metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Calcitriol in cancer treatment: from the lab to the clinic.
Beer and Myrthue
Mol.Cancer Ther., 2004;3:373
The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.
Nijenhuis et al.
FASEB J., 2006;20:1589
The in vitro effect of calci. on parathyroid cell proliferation and apoptosis.
Canalejo et al.
Citations for Calcitriol
The citations listed below are publications that use Tocris products. Selected citations for Calcitriol include:
2 Citations: Showing 1 - 2
A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.
Authors: Sharma Et al.
Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification.
Authors: Pal Et al.
J Neurosci 2010;210:88
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