Calcitriol (CAS 32222-06-3): R&D Systems
Catalog Number: 2551
Alternate Names: 1,25-Dihydroxyvitamin D3
Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
Biological Activity
Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
Technical Data
  • M.Wt:
    416.64
  • Formula:
    C27H44O3
  • Solubility:
    Soluble in DMSO and in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    32222-06-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis.
    Canalejo et al.
    J.Am.Soc.Nephrol., 2000;11:1865
  2. Calcitriol in cancer treatment: from the lab to the clinic.
    Beer and Myrthue
    Mol.Cancer Ther., 2004;3:373
  3. The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.
    Nijenhuis et al.
    FASEB J., 2006;20:1589
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calcitriol include:

2 Citations: Showing 1 - 2
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  1. A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.
    Authors: Sharma Et al.
    Atherosclerosis 2015;10:2346
  2. Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification.
    Authors: Pal Et al.
    J Neurosci 2010;210:88
Tocris Small Molecules
Description Application Cat# Citations Images  

Calcifediol

4036 1  
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