Calcitriol

Catalog # Availability Size / Price Qty
2551/50U
Calcitriol | CAS No. 32222-06-3 | VDR-like Receptor Agonists
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Description: Vitamin D receptor (VDR) agonist
Alternative Names: 1,25-Dihydroxyvitamin D3

Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol

Purity: ≥99%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data

M.Wt:
416.64
Formula:
C27H44O3
Solubility:
Soluble in DMSO and in ethanol
Purity:
≥99%
Storage:
Desiccate at -20°C
CAS No:
32222-06-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Calcitriol in cancer treatment: from the lab to the clinic.
    Beer and Myrthue
    Mol.Cancer Ther., 2004;3:373
  2. The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist.
    Nijenhuis et al.
    FASEB J., 2006;20:1589
  3. The in vitro effect of calci. on parathyroid cell proliferation and apoptosis.
    Canalejo et al.
    J.Am.Soc.Nephrol., 2000;11:1865

Product Datasheets

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Citations for Calcitriol

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2 Citations: Showing 1 - 2

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