Catalog Number: 0476
Biological Activity
GTP cyclohydrolase I (GCH1) inhibitor. Prevents the de novo synthesis of tetrahydrobiopterin (BH4) and thus suppresses the activity of NO synthase. Exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein).
Technical Data
  • M.Wt:
    126.12
  • Formula:
    C4H6N4O
  • Solubility:
    Soluble in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    56-06-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system?
    Moore and Handy
    TiPS, 1997;18:204
  2. Pteridine biosynthesis in human endothelial cells. Impact of NO-mediated formation of cyclic GMP.
    Werner-Felmayer et al.
    J.Biol.Chem., 1993;268:1842
  3. GTP cyclohydrolase I inhibition by the prototypic inhibitor 2,4-diamino-6-hydroxypyrimidine.
    Xie et al.
    J.Biol.Chem., 1998;273:21091

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