25-Hydroxycholesterol
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Description: Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone
Chemical Name: Cholest-5-ene-3β,25-diol
Purity: ≥95%
Biological Activity
25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.Technical Data
M.Wt:
402.65
Formula:
C27H46O2
Solubility:
Soluble to 20 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2140-46-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
-
MicroRNAs regulate the immunometabolic response to viral infection in the liver.
Singaravelu et al.
Nat.Chem.Biol., 2015;11:988 -
Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models.
Makley et al.
Science, 2015;350:674
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