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25-Hydroxycholesterol

Catalog #: 5741
2 Citations Datasheet / COA / SDS
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5741/10

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25-Hydroxycholesterol | CAS No. 2140-46-7 | Antiviral Compounds
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Description: Inhibits hepatitis C viral life cycle; also α-crystallin (cryAB) chaperone

Chemical Name: Cholest-5-ene-3β,25-diol

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.

Technical Data

M.Wt:
402.65
Formula:
C27H46O2
Solubility:
Soluble to 20 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2140-46-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 25-Hydroxycholesterol

The citations listed below are publications that use Tocris products. Selected citations for 25-Hydroxycholesterol include:

2 Citations: Showing 1 - 2

  1. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types.
    Authors: Judith Et al.
    iScience  2022;25:103848
  2. Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production.
    Authors: Keith S Et al.
    Sci Rep  2021;11:16347

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