Chemical Name: Cholest-5-ene-3β,25-diol
Biological Activity25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.
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MicroRNAs regulate the immunometabolic response to viral infection in the liver.
Singaravelu et al.
Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models.
Makley et al.
Citations for 25-Hydroxycholesterol
The citations listed below are publications that use Tocris products. Selected citations for 25-Hydroxycholesterol include:
2 Citations: Showing 1 - 2
Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types.
Authors: Judith Et al.
Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production.
Authors: Keith S Et al.
Sci Rep 2021;11:16347
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