Chemical Name: Cholest-5-ene-3β,25-diol
Biological Activity25-Hydroxycholesterol is an antiviral. Stimulates expression of miR-185 microRNA which inhibits the hepatitis C virus life cycle via inhibition of cholesterol biosynthesis and virus cell membrane fusion. Also α-crystallin (cryAB) chaperone (Kd = 10.1 μM). Blocks α-crystallin aggregation and partially reverses cataract formation by binding and stabilizing soluble forms of cryAB in vitro and in vivo.
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MicroRNAs regulate the immunometabolic response to viral infection in the liver.
Singaravelu et al.
Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models.
Makley et al.
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