(2R,4R)-APDC

Key Product Details

Product Description

(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC₅₀ values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu₂, mGlu₃, mGlu₁, mGlu₅, mGlu₄ and mGlu₇ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold with the permission of Eli Lilly and Company

Product Specifications for (2R,4R)-APDC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (2R,4R)-APDC

The following data is based on the product molecular weight 174.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.74 mL	28.71 mL	57.42 mL
5 mM	1.15 mL	5.74 mL	11.48 mL
10 mM	0.57 mL	2.87 mL	5.74 mL
50 mM	0.11 mL	0.57 mL	1.15 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

• Schoepp Selective inhibition of forskolin-stimulated cyclic AMP formation in rat hippocampus by a novel mGluR agonist, 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate. Neuropharmacology 1995 PMID: 8532165
• Schoepp Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 1999 PMID: 10530808
• Monn Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase. J.Med.Chem. 1996 PMID: 8709133

Product Documents for (2R,4R)-APDC