3-Deazaneplanocin A hydrochloride

Catalog # Availability Size / Price Qty
4703/1
Cat.No. 4703 - 3-Deazaneplanocin A hydrochloride | C12H14N4O3.HCl | CAS No. 120964-45-6
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Description: EZH2 histone methyltransferase inhibitor
Alternative Names: DZNep, NSC 617989

Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Histone methyltransferase inhibitor; decreases global histone methylation. Inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. Induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

Technical Data

M.Wt:
298.73
Formula:
C12H14N4O3.HCl
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
120964-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 3-Deazaneplanocin A hydrochloride

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