3-Deazaneplanocin A hydrochloride
Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride
Purity: ≥98%
Biological Activity
3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).DZNep synthesized to Ancillary Material Grade also available.
For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Tan J, Yang X, Zhuang L et al.
Genes Dev. -
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Miranda et al.
Mol.Cancer Ther., 2009;8:1579 -
Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities.
Tseng et al.
J.Med.Chem., 1989;32:1442 -
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
Hou et al.
Science, 2013;341:651
Product Datasheets
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Citations for 3-Deazaneplanocin A hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 3-Deazaneplanocin A hydrochloride include:
4 Citations: Showing 1 - 4
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Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs.
Authors: Ping Et al.
Cell Death Dis 2018;9:187
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Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
Authors: Wang Et al.
Stem Cell Res Ther 2017;8:245
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The role of microRNA-5196 in the pathogenesis of systemic sclerosis.
Authors: Jerzy Et al.
Eur J Clin Invest 2017;47:555-564
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Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2.
Authors: Stefan Et al.
Arthritis Rheumatol 2016;68:1493-504
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