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3-Deazaneplanocin A hydrochloride

4703 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4703/1

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3-Deazaneplanocin A hydrochloride | CAS No. 120964-45-6 | EZH2 Inhibitor
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Description: EZH2 histone methyltransferase inhibitor
Alternative Names: DZNep, NSC 617989

Chemical Name: (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

3-Deazaneplanocin A hydrochloride is a histone methyltransferase inhibitor; decreases global histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).

DZNep synthesized to Ancillary Material Grade also available.

For more information about how 3-Deazaneplanocin A hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

Technical Data

M.Wt:
298.73
Formula:
C12H14N4O3.HCl
Solubility:
Soluble to 10 mM in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
120964-45-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 3-Deazaneplanocin A hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 3-Deazaneplanocin A hydrochloride include:

2 Citations: Showing 1 - 2

  1. Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs.
    Authors: Ping Et al.
    Cell Death Dis  2018;9:187
  2. Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells.
    Authors: Wang Et al.
    Stem Cell Res Ther  2017;8:245

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