Chemical Name: α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
Biological ActivityPotent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3 μM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300 μM), NMDA and AMPA (IC50 = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death.
Moroni et al.
Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity?
Cozzi et al.
Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist.
Constantino et al.
Il Farmaco, 2004;59:93
Citation for 3-MATIDA
The citations listed below are publications that use Tocris products. Selected citations for 3-MATIDA include:
1 Citation: Showing 1 - 1
Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
Authors: Zheng and Raman
J Neurosci 2011;31:10283
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