3-MATIDA

  ( 1 citations )    
Product Datasheet
Catalog Number:2196
Chemical Name:α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Potent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3 μM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300 μM), NMDA and AMPA (IC50 = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.
Technical Data
  • M.Wt:
    215.23
  • Formula:
    C8H9NO4S
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    518357-51-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 3-MATIDA include:

1 Citations: Showing 1 - 1

  1. Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
    Authors: Zheng and Raman
    J Neurosci  2011;31:10283

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