Chemical Name:α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
Biological Activity Potent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3 μM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300 μM), NMDA and AMPA (IC50 = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.
Soluble to 100 mM in 1eq. NaOH and to 50 mM in DMSO
Store at +4°C
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