3-MATIDA

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2196/10
2196/50
3-MATIDA | CAS No. 518357-51-2 | Group I mGluR Antagonists
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Description: Potent and selective mGlu1 antagonist

Chemical Name: α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Potent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3 μM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300 μM), NMDA and AMPA (IC50 = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.

Technical Data

M.Wt:
215.23
Formula:
C8H9NO4S
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
518357-51-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 3-MATIDA

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