Chemical Name: 3-Methyl-3H-purin-6-amine
Biological Activity3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
Blommaart et al.
Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
Canu et al.
3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
Seglen and Gordon
Proc.Natl.Acad.Sci. USA, 1982;79:1889
Citations for 3-Methyladenine
The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:
8 Citations: Showing 1 - 8
Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in PTX-Resistant Ovarian Cancer Cells.
Authors: Park Et al.
Mar Drugs 2019;17
Junín virus induces autophagy in human A549 cells.
Authors: Vidakovics Et al.
PLoS One 2019;14:e0218730
Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.
Authors: Sagrillo-Fagundes Et al.
PLoS One 2019;14:e0202458
A role for autophagy in long-term spatial memory formation in male rodents.
Authors: Hylin Et al.
J Neurosci Res 2018;96:416
Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.
Authors: Nepal Et al.
Evid Based Complement Alternat Med 2015;6:7166
Miz1 is required to maintain autophagic flux.
Authors: Wolf Et al.
Clin Transl Med 2013;4:2535
Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
Authors: Kim Et al.
J Biol Chem 2013;288:22693
Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
Authors: Wang Et al.
Nat Commun 2013;2013:857929
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