Catalog Number: 3977
Alternate Names: 3-MA
Chemical Name: 3-Methyl-3H-purin-6-amine
Biological Activity
Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
Technical Data
  • M.Wt:
    149.15
  • Formula:
    C6H7N5
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    5142-23-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
    Blommaart et al.
    Eur.J.Biochem., 1997;243:240
  2. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
    Canu et al.
    J.Neurochem., 2005;92:1228
  3. 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
    Seglen and Gordon
    Proc.Natl.Acad.Sci. USA, 1982;79:1889
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.
    Authors: Nepal Et al.
    Evid Based Complement Alternat Med 2015;6:7166
  2. Miz1 is required to maintain autophagic flux.
    Authors: Wolf Et al.
    Clin Transl Med 2013;4:2535
  3. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem 2013;288:22693
  4. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    Nat Commun 2013;2013:857929

Have you used 3-Methyladenine?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information