Catalog Number: 3977
Alternate Names: 3-MA
Chemical Name: 3-Methyl-3H-purin-6-amine
Biological Activity
Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
    Blommaart et al.
    Eur.J.Biochem., 1997;243:240
  2. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
    Canu et al.
    J.Neurochem., 2005;92:1228
  3. 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
    Seglen and Gordon
    Proc.Natl.Acad.Sci. USA, 1982;79:1889

The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:

Showing Results 1 - 4 of 4

  1. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.
    Authors: Nepal Et al.
    Evid Based Complement Alternat Med
  2. Miz1 is required to maintain autophagic flux.
    Authors: Wolf Et al.
    Clin Transl Med
  3. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem
  4. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    Nat Commun
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