3-Methyladenine

Catalog # Availability Size / Price Qty
3977/50
PI 3-Kinase Inhibitors Small Molecule
1 Image
Description: Class III PI 3-kinase inhibitor; also inhibits autophagy
Alternative Names: 3-MA

Chemical Name: 3-Methyl-3H-purin-6-amine

Purity: ≥99%

Product Details
Citations (6)
Reviews

Biological Activity

Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.

Technical Data

M.Wt:
149.15
Formula:
C6H7N5
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
5142-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
    Blommaart et al.
    Eur.J.Biochem., 1997;243:240
  2. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
    Canu et al.
    J.Neurochem., 2005;92:1228
  3. 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
    Seglen and Gordon
    Proc.Natl.Acad.Sci. USA, 1982;79:1889

Product Datasheets

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Citations for 3-Methyladenine

The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:

6 Citations: Showing 1 - 6

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