Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
Soluble to 20 mM in DMSO
Store at +4°C
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The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
Blommaart et al.
Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
Canu et al.
3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
Seglen and Gordon
Proc.Natl.Acad.Sci. USA, 1982;79:1889
The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:
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