3-Methyladenine

  ( 4 citations )    
Product Datasheet
Catalog Number:3977
Alternate Names:3-MA
Chemical Name:3-Methyl-3H-purin-6-amine
Product Details
Citations (4)
Reviews
Biological Activity
Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.
Technical Data
  • M.Wt:
    149.15
  • Formula:
    C6H7N5
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    5142-23-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:

4 Citations: Showing 1 - 4
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  1. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.
    Authors: Nepal Et al.
    Evid Based Complement Alternat Med  2015;6:7166
  2. Miz1 is required to maintain autophagic flux.
    Authors: Wolf Et al.
    Clin Transl Med  2013;4:2535
  3. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem  2013;288:22693
  4. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    Nat Commun  2013;2013:857929

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