Catalog # Availability Size / Price Qty
3-Methyladenine | CAS No. 5142-23-4 | PI 3-Kinase Inhibitors
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Description: Class III PI 3-kinase inhibitor; also inhibits autophagy
Alternative Names: 3-MA

Chemical Name: 3-Methyl-3H-purin-6-amine

Purity: ≥99%

Product Details
Citations (8)

Biological Activity

3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.

Technical Data

Soluble to 20 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
    Blommaart et al.
    Eur.J.Biochem., 1997;243:240
  2. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
    Canu et al.
    J.Neurochem., 2005;92:1228
  3. 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
    Seglen and Gordon
    Proc.Natl.Acad.Sci. USA, 1982;79:1889

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Citations for 3-Methyladenine

The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:

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