Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
Biological Activity Originally reported to inhibit PFKFB3 (IC50 = 25 μM). More recent reports failed to demonstrate activity in a PFKFB3 kinase assay. Reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.
Soluble to 100 mM in DMSO
Store at -20°C
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