PFKFB3 Compounds

PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3) is an enzyme that plays a key role in the regulation of glycolysis in rapidly dividing cells, so is important in cancer metabolism and during development. PFKFB3 is present in a wide variety of tissues and is induced under hypoxic conditions. The enzyme is one of four PFKFB isozymes and differs from other family members in that it has a very high kinase:phosphatase activity ratio and is overexpressed in a range of cancer types. It ...