4-Aminopyridine

Tocris Bioscience | Catalog # 0940

Non-selective KV channel blocker
Tocris Bioscience

Key Product Details

Description

Non-selective KV channel blocker

Alternative Names

4-AP
View all Voltage-gated Potassium Channel Blockers »

Product Description

4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.

Product Specifications for 4-Aminopyridine

Molecular Weight

94.12

Formula

C5H6N2

Storage

Store at RT

Purity

≥98% (HPLC)

CAS Number

504-24-5

PubChem ID

1727

InChI Key

NUKYPUAOHBNCPY-UHFFFAOYSA-N

SMILES

NC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.41 100
DMSO 9.41 100

Preparing Stock Solutions for 4-Aminopyridine

The following data is based on the product molecular weight 94.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 10.62 mL 53.12 mL 106.25 mL
5 mM 2.12 mL 10.62 mL 21.25 mL
10 mM 1.06 mL 5.31 mL 10.62 mL
50 mM 0.21 mL 1.06 mL 2.12 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 290 publications citing the usage of this product.

Product Documents for 4-Aminopyridine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 4-Aminopyridine

For research use only

Citations for 4-Aminopyridine

Customer Reviews for 4-Aminopyridine (2)

4.5 out of 5
2 Customer Ratings
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  • Product performed ideally over years and would buy again.
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    We increased synaptic activity using a standard pharmacological approach (20 μM bicuculline and 100 μM 4-AP.
    4-Aminopyridine 0940
  • Product performed ideally over years and would buy again
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/15/2018
    Our cell biology lab uses 4 Aminopyridine block Kv channels on different cell lines expressing different Kv channel from all across human body. The product works excellent and few papers have been published where it has been used. Greatly recommend.
    4-Aminopyridine 0940

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