Catalog Number: 0940
Alternate Names: 4-AP
Biological Activity
Non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Caged 4-AP (Cat. No. 3557) is also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5.
    Bouchard and Fedida
    J.Pharmacol.Exp.Ther., 1995;275:864
  2. In vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative.
    Smith et al.
    Clin.Exp.Pharmacol.Physiol., 2009;36:1104
  3. Reverse use dependence of Kv4.2 blockade by 4-aminopyridine.
    Tseng et al.
    J.Pharmacol.Exp.Ther., 1996;279:865
  4. Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.
    J.Pharmacol.Exp.Ther., 1999;290:569

The citations listed below are publications that use Tocris products. Selected citations for 4-Aminopyridine include:

Showing Results 1 - 10 of 21

  1. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus.
    Authors: Dinamarca Et al.
  2. Tissue plasminogen activator inhibits NMDA-receptor-mediated increases in calcium levels in cultured hippocampal neurons.
    Authors: Robinson Et al.
    J Neurosci
  3. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    J Neurosci
  4. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Front Neural Circuits
  5. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Front Cell Neurosci
  6. Neuronal activity induces synaptic delivery of hnRNP A2/B1 by a BDNF-dependent mechanism in cultured hippocampal neurons.
    Authors: Leal Et al.
    PLoS One
  7. Generation of induced neuronal cells by the single reprogramming factor ASCL1.
    Authors: Chanda Et al.
    J Neurosci
  8. Identification of a pharmacological target for genioglossus reactivation throughout sleep.
    Authors: Grace Et al.
  9. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation.
    Authors: Chanda Et al.
    J Biol Chem
  10. Optophysiological analysis of associational circuits in the olfactory cortex.
    Authors: Hagiwara Et al.
    Cell Death Dis
  11. Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
    Authors: Kaufman Et al.
  12. The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
    Authors: Shulga Et al.
    J Neurosci
  13. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci
  14. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    J Neurophysiol
  15. The A-current modulates learning via NMDA receptors containing the NR2B subunit.
    Authors: Fontán-Lozano Et al.
    PLoS One
  16. Synaptic autoregulation by metalloproteases and γ-secretase.
    Authors: Restituito Et al.
    J Neurosci
  17. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol
  18. Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV.
    Authors: Sun
    EMBO J
  19. Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
    Authors: Léveillé Et al.
  20. Dopaminergic modulation of spinal neuronal excitability.
    Authors: Han Et al.
    J Neurophysiol
  21. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    Stem Cell Reports
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