Catalog Number: 3429
Chemical Name: 4-Iodo-6-phenylpyrimidine
Biological Activity
Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
    Winner et al.
    Cancer Res., 2008;68:7253

The citations listed below are publications that use Tocris products. Selected citations for 4-IPP include:

Showing Results 1 - 2 of 2

  1. Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
    Authors: Subbannayya Et al.
    J Biol Chem
  2. The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.
    Authors: Salazar Et al.
    Mol Cancer
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information