Chemical Name: 4-Iodo-6-phenylpyrimidine
Biological ActivityInhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Winner et al.
Cancer Res., 2008;68:7253
Citations for 4-IPP
The citations listed below are publications that use Tocris products. Selected citations for 4-IPP include:
3 Citations: Showing 1 - 3
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
Authors: Subbannayya Et al.
J Biol Chem 2015;15:843
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.
Authors: Salazar Et al.
Mol Cancer 2014;13:198
Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses.
Authors: Takahashi Et al.
PLoS One 2013;8:e78250
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for 4-IPP
There are currently no reviews for this product. Be the first to review 4-IPP and earn rewards!
Have you used 4-IPP?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image