Chemical Name: 4-Iodo-6-phenylpyrimidine
Biological Activity4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Winner et al.
Cancer Res., 2008;68:7253
Citations for 4-IPP
The citations listed below are publications that use Tocris products. Selected citations for 4-IPP include:
4 Citations: Showing 1 - 4
Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression.
Authors: Justin D Et al.
Front Immunol 2020;11:1191
Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
Authors: Subbannayya Et al.
J Biol Chem 2015;15:843
The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.
Authors: Salazar Et al.
Mol Cancer 2014;13:198
Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses.
Authors: Takahashi Et al.
PLoS One 2013;8:e78250
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