Catalog Number: 3429
Chemical Name: 4-Iodo-6-phenylpyrimidine
Biological Activity
Inhibitor of macrophage migration inhibitory factor (MIF). Acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Also inhibits migration and anchorage independence of human lung adenocarcinoma cell lines in vitro.
Technical Data
  • M.Wt:
    282.08
  • Formula:
    C10H7IN2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    41270-96-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
    Winner et al.
    Cancer Res., 2008;68:7253
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 4-IPP include:

2 Citations: Showing 1 - 2
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  1. Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer.
    Authors: Subbannayya Et al.
    J Biol Chem 2015;15:843
  2. The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation.
    Authors: Salazar Et al.
    Mol Cancer 2014;13:198

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