4-Methylhistamine dihydrochloride

Key Product Details

Product Description

4-Methylhistamine dihydrochloride is a potent, high affinity H₄ receptor agonist (K_i = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

Product Specifications for 4-Methylhistamine dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for 4-Methylhistamine dihydrochloride

The following data is based on the product molecular weight 198.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	10.10 mL	50.48 mL	100.96 mL
2.5 mM	2.02 mL	10.10 mL	20.19 mL
5 mM	1.01 mL	5.05 mL	10.10 mL
25 mM	0.20 mL	1.01 mL	2.02 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Gbahou Compared pharmacology of human histamine H₃ and H₄ receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol
• Lim Evaluation of histamine H₁-, H₂-, and H₃-receptor ligands at the human histamine H₄ receptor: identification of 4-methylhistamine as the first potent and selective H₄ receptor agonist. J.Pharmacol.Exp.Ther. 2005 PMID: 15947036

Product Documents for 4-Methylhistamine dihydrochloride