Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Biological Activity4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
Lim et al.
Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.
Gbahou et al.
Citations for 4-Methylhistamine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:
4 Citations: Showing 1 - 4
Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
Authors: Kim Et al.
Korean J Physiol Pharmacol 2013;17:149
Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
Authors: Desmadryl Et al.
Br J Pharmacol 2012;167:905
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
Authors: Connelly Et al.
Br J Pharmacol 2009;157:55
Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
Authors: Holden Et al.
Bone Joint Res 2007;152:891
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