Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Biological ActivityPotent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
Lim et al.
Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.
Gbahou et al.
Citations for 4-Methylhistamine dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:
4 Citations: Showing 1 - 4
Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
Authors: Kim Et al.
Korean J Physiol Pharmacol 2013;17:149
Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.
Authors: Desmadryl Et al.
Br J Pharmacol 2012;167:905
The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS.
Authors: Connelly Et al.
Br J Pharmacol 2009;157:55
Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
Authors: Holden Et al.
Bone Joint Res 2007;152:891
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for 4-Methylhistamine dihydrochloride
There are currently no reviews for this product. Be the first to review 4-Methylhistamine dihydrochloride and earn rewards!
Have you used 4-Methylhistamine dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image