Catalog Number: 2342
Chemical Name: 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride
Biological Activity
Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist.
    Lim et al.
    J.Pharmacol.Exp.Ther., 2005;314:1310
  2. Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives.
    Gbahou et al.
    Br.J.Pharmacol, 2006;147:74

The citations listed below are publications that use Tocris products. Selected citations for 4-Methylhistamine dihydrochloride include:

Showing Results 1 - 2 of 2

  1. Effects of histamine on cultured interstitial cells of cajal in murine small intestine.
    Authors: Kim Et al.
    Korean J Physiol Pharmacol
  2. Potentiation of NF-κB-dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells.
    Authors: Holden Et al.
    Bone Joint Res
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