Catalog Number: 1034
Alternate Names: AH 024
Chemical Name: cis-4-Phenyl-2-propionamidotetralin
Biological Activity
Melatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.
Technical Data
  • M.Wt:
    279.38
  • Formula:
    C19H21NO
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    620170-78-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melatonin receptors: are there multiple subtypes?
    Dubocovich
    TiPS, 1995;16:50
  2. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor.
    Dubocovich et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:365
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 4-P-PDOT include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
    Authors: Chen Et al.
    J Clin Invest 2014;20:1298
  2. MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
    Authors: Tunstall Et al.
    J Pharmacol Exp Ther 2011;336:127
  3. Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
    Authors: Jones Et al.
    Biochem Pharmacol 2010;80:1478
  4. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development.
    Authors: Danilova Et al.
    J Pharmacol Exp Ther 2004;18:751
  5. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
    Authors: Sjöblom Et al.
    FASEB J 2001;108:625

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