Chemical Name: cis-4-Phenyl-2-propionamidotetralin
Biological ActivityMelatonin receptor antagonist, >300-fold selective for the MT2 (vs MT1) subtype.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Melatonin receptors: are there multiple subtypes?
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor.
Dubocovich et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:365
Citations for 4-P-PDOT
The citations listed below are publications that use Tocris products. Selected citations for 4-P-PDOT include:
8 Citations: Showing 1 - 8
Homeostatic Plasticity Mediated by Rod-Cone Gap Junction Coupling in Retinal Degenerative Dystrophic RCS Rats.
Authors: Hou Et al.
Front Cell Neurosci 2017;11:98
Antinociceptive effects of novel melatonin receptor agonists in mouse models of abdominal pain.
Authors: Chen Et al.
J Clin Invest 2014;20:1298
Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.
Authors: Faria Et al.
Am J Physiol Endocrinol Metab 2013;305:E230
MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.
Authors: Tunstall Et al.
J Pharmacol Exp Ther 2011;336:127
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
Authors: Jones Et al.
Biochem Pharmacol 2010;80:1478
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Authors: Zhao Et al.
J Physiol 2010;588:2605
Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development.
Authors: Danilova Et al.
J Pharmacol Exp Ther 2004;18:751
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Authors: Sjöblom Et al.
FASEB J 2001;108:625
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