4-Thiouridine
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Description: Photoreactive uridine analog for RNA sequencing
Chemical Name: 4-Thiouridine
Purity: ≥98%
Biological Activity
4-Thiouridine is a photoreactive uridine analog for RNA sequencing (RNA seq) and thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM seq). Used as a crosslinker to identify RNA binding proteins. Is incorporated into newly transcribed RNA and can be used to track RNA from synthesis to degradation.Technical Data
M.Wt:
260.26
Formula:
C9H12N2O5S
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
13957-31-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding.
Schofield et al.
Nat.Methods, 2018;15:221 -
Isolation of newly transcribed RNA using the metabolic label 4-thiouridine.
Garibaldi et al.
Methods Mol.Biol., 2017;1648:169 -
Thiol-linked alkylation of RNA to assess expression dynamics.
Herzog et al.
Nat.Methods, 2017;14:1198
Product Datasheets
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