Chemical Name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol
Biological Activity4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Nav1.6 voltage-dependent sodium channel.
Rosker et al.
Am.J.Physiol.Cell Physiol., 2007;293:C783
Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis
Hargus et al.
Citation for 4,9-Anhydrotetrodotoxin
The citations listed below are publications that use Tocris products. Selected citations for 4,9-Anhydrotetrodotoxin include:
1 Citation: Showing 1 - 1
The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform.
Authors: Vysokov Et al.
Sci Rep 2019;9:12915
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