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4,9-Anhydrotetrodotoxin

Catalog #: 6159
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6159/100U
4,9-Anhydrotetrodotoxin | CAS No. 13072-89-4 | Voltage-gated Sodium Channel Blockers
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Description: Potent and selective Nav1.6 channel blocker
Alternative Names: 4,9-anhydro-TTX

Chemical Name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).

Technical Data

M.Wt:
301.25
Formula:
C11H15N3O7
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
13072-89-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for 4,9-Anhydrotetrodotoxin

The citations listed below are publications that use Tocris products. Selected citations for 4,9-Anhydrotetrodotoxin include:

1 Citation: Showing 1 - 1

  1. The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform.
    Authors: Vysokov Et al.
    Sci Rep  2019;9:12915

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