4,9-Anhydrotetrodotoxin

Tocris Bioscience | Catalog # 6159

Potent and selective Nav1.6 channel blocker
Tocris Bioscience
Discontinued Product
6159 has been discontinued. View all Voltage-gated Sodium Channel Blockers products.

Key Product Details

Description

Potent and selective Nav1.6 channel blocker

Alternative Names

4,9-anhydro-TTX
View all Voltage-gated Sodium Channel Blockers »

Product Description

4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and >30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).

Product Specifications for 4,9-Anhydrotetrodotoxin

Molecular Weight

301.25

Formula

C11H15N3O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

CAS Number

13072-89-4

PubChem ID

11243537

InChI Key

STNXQECXKDMLJK-PZKHIREQSA-N

SMILES

O[C@@]1(CO)[C@H](O2)[C@H]([C@H](O3)NC(N4[H])=N)[C@]54[C@H]3[C@@]2(O)O[C@H]1[C@H]5O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1 4

Preparing Stock Solutions for 4,9-Anhydrotetrodotoxin

The following data is based on the product molecular weight 301.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.04 mM 82.99 mL 414.94 mL 829.88 mL
0.2 mM 16.60 mL 82.99 mL 165.98 mL
0.4 mM 8.30 mL 41.49 mL 82.99 mL
2 mM 1.66 mL 8.30 mL 16.60 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

Product Documents for 4,9-Anhydrotetrodotoxin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 4,9-Anhydrotetrodotoxin

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for 4,9-Anhydrotetrodotoxin

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