Tetrodotoxin

Tocris Bioscience | Catalog # 1078

Na+ channel blocker
Tocris Bioscience

Key Product Details

Description

Na+ channel blocker

Alternative Names

TTx
View all Voltage-gated Sodium Channel Blockers »

Product Description

Tetrodotoxin is a reversible, potent, selective and high affinity inhibitor of voltage gated sodium channels Nav 1.6, 1.1, 1.3, 1.4, 1.2 and 1.7 (IC50 values are 2.3 nM, 4.1 nM, 5.3 nM, 7.6 nM, 14 nM and 36 nM, respectively). Binding is reversible and high affinity (Kd = 1-10 nM). Tetrodotoxin shows antagonism of aconitine-induced cardiac toxicity, analgesic effects in mouse models of neuropathy and prolonged duration of local anesthesia in animals when combined with capsaicin. Tetrodotoxin also shows pH-dependent blockade of canine cardiac L-type Ca2+ (Cav1.x) channels, blocks primary reward in an animal study of drug-seeking lever pressing.

Tetrodotoxin citrate (Cat. No. 1069) also available.

Product Specifications for Tetrodotoxin

Molecular Weight

319.27

Formula

C11H17N3O8

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol

CAS Number

4368-28-9

PubChem ID

16759596

InChI Key

CFMYXEVWODSLAX-CKYAAQHSSA-N

SMILES

OC1(CO)[C@H](O4)C(O)[C@@]2([C@@H]([C@@H](O)N3)C1O[C@](O)4[C@H]2O)NC3=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 2011 publications citing the usage of this product.

Product Documents for Tetrodotoxin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tetrodotoxin

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for Tetrodotoxin (5)

4.8 out of 5
5 Customer Ratings
5 Stars
80%
4 Stars
20%
3 Stars
0%
2 Stars
0%
1 Stars
0%

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Showing  1 - 5 of 5 reviews Showing All
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  • Totally blocked action potential
    Name: Yuyang Sun
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 05/30/2022
    Works great. Totally blocked the action potential in mouse brain slice.
    Tetrodotoxin 1078
  • Validation
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    10 μM for 30min
    Tetrodotoxin 1078
  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: skate
    Assay Type: In Vitro
    Verified Customer | Posted 02/28/2020
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    Tetrodotoxin 1078
  • TTX blocks action potential propagation
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 08/31/2019
    Compound should be sonicated when dissolved.
    Tetrodotoxin (TTX) was used to block action potential propagation in response to lasting current injection into living neuron. This illustrated a critical role of voltage-gated sodium channels in inter-neuronal crosstalk. 1 microM of TTX developed 100% effect (see Figure). Figure: action potential generation by isolated neuron under control and after TTX was added to perfusion solution.
    Tetrodotoxin 1078
  • good drug for neuronal activity inhibition
    Name: Lihua Wang
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 01/24/2018
    We use this to block cell activity of the brain slices, in order to keep the cells more healthy after they are dissociated. It works great and helps a lot for our purpose; but the only little problem is that it's very hard to dissolve in the water.

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