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5-Ph-IAA-AM | TAG Degradation Platforms
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Description: Selective and potent TAG Degrader for auxin-inducible degron 2 system; 5-Ph-IAA analog

Chemical Name: Acetoxymethyl 2-(5-phenyl-1H-indol-3-yl)acetate

Purity: ≥98%

Product Details

Biological Activity

5-Ph-IAA-AM is a potent and selective "Bump & Hole" TAG Degrader, for use within an auxin-inducible degron (AID2) system; it is an egg-permeant analog of 5-Ph-IAA (Cat. No.7392). 5-Ph-IAA-AM induces selective degradation of a target protein tagged with a single-point mutant AtTIR1F79G F-box protein. 5-Ph-IAA-AM induces target protein degradation in C. elegans embryos. No developmental abnormality is observed when the embryos are treated with 50 μM 5-Ph-IAA-AM.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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