63 results for "tag-degradation-platforms" in Products

 View condensed search

Janelia Fluor® 525, BromoCatch™ Ligand

Catalog #: 8997
Product Documents

Fluorogenic Janelia Fluor® 525 conjugated covalent ligand for BromoCatch™, enabling no-wash live-cell imaging

Chemical Name: 4-(((R)-14-((S)-4-(4-Acrylamidophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-13-oxo-3,6,9-trioxa-12-azahexadecyl)carbamoyl)-2-(3-(3,3-difluoroazetidin-1-ium-1-ylidene)-6-(3,3-difluoroazetidin-1-yl)-3H-xanthen-9-yl)benzoate
Purity: ≥90%
Fluorogenic Janelia Fluor® 525 conjugated covalent ligand for BromoCatch™, enabling no-wash live-cell imaging

BromoCatch™ Control Ligand

Catalog #: 7300
Product Documents

Control ligand for use with BromoCatch™, a Self-Labeling Proteins (SLPs) tag platform

Alternate Names: Et-JQ1-OMe
Chemical Name: Methyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate
Purity: ≥97%
Use of BromoCatch™ Control Ligand in live cell imaging
(2)

dTAGV-1

Catalog #: 6914
(2)
Citations (85)
Product Documents

Potent and selective degrader of mutant FKBP12F36V fusion proteins

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate trifluoroacetate
Purity: ≥98%
Potent and selective degrader of mutant FKBP12F36V fusion proteins

dTAG-13

Catalog #: 6605
(4)
Citations (137)
Product Documents

Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥98%
Degrades mutant FKBP12F36V fusion proteins; useful alternative to genetic methods for target validation

BromoCatch™ Expression Plasmid (N-term, His tag, pCMV, Puro)

Catalog #: RDEH-BC03
Product Documents
R&D Systems VersaClone cDNA Plasmids

dTAG-13-NEG

Catalog #: 6916
Citations (4)
Product Documents

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name: 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity: ≥97%
Negative control for dTAG-13 (Cat. No. 6605)

dTAGV-1-NEG

Catalog #: 6915
(1)
Citations (11)
Product Documents

Negative control for dTAGV-1 (Cat. No. 6914)

Chemical Name: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-(((S)-1-((2R,4S)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
Purity: ≥98%
Negative control for dTAGV-1 (Cat. No. 6914)

aTAG 4531

Catalog #: 6971
Citations (1)
Product Documents

Degrader of MTH1 fusion proteins for use within the aTAG system

Alternate Names: CFT 4531
Chemical Name: N-Cyclopropyl-6-(4-((4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)butyl)carbamoyl)-3-fluorophenyl)-7-fluoro-4-(phenylamino)quinoline-3-carboxamide
Purity: ≥98%
Degrader of MTH1 fusion proteins for use within the aTAG system

BromoTag® AGB1

Catalog #: 7686
Citations (12)
Product Documents

Potent and selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name: (S)-13-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl (R)-2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)butanoate
Purity: ≥98%
Live-cell luminescent kinetic degradation assay
(2)

BromoTag® AGB3

Catalog #: 7688
Product Documents

Selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)

Chemical Name: (2S,4R)-1-((2S,17R)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazanonadecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98%
Selective Degrader of Brd4BD2 L387A fusion proteins (BromoTag®)
Results Per Page
5 10 25 50