Highly selective adenosine A1
receptor agonist (Ki
values are 0.51, 1290, 1340 and 2740 nM at A1
receptors respectively). Reverses formaline-induced nocifensive behavior in mice; antinociceptive.
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All Tocris products are intended for laboratory research use only.
N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor.
Trivedi et al.
N6-cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.
Franchetti et al.