680C91

Catalog # Availability Size / Price Qty
4392/25
4392/5
Tryptophan 2,3 Dioxygenase Inhibitors Small Molecule
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Description: Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM). Exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Produces large increases in brain tryptophan and serotonin in vitro and in vivo in the rat.

Technical Data

M.Wt:
238.26
Formula:
C15H11FN2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
163239-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for 680C91

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