Catalog Number: 4392
Chemical Name: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole
Biological Activity
Potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) (Ki = 51 nM). Exhibits no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors. Produces large increases in brain tryptophan and serotonin in vitro and in vivo in the rat.
Technical Data
  • M.Wt:
    238.26
  • Formula:
    C15H11FN2
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    163239-22-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
    Opitz et al.
    Nature, 2011;478:197
  2. The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat.
    Salter et al.
    Biochem.Pharmacol., 1995;17:1435
  3. The effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat.
    Salter et al.
    Neuropharmacology, 1995;34:217
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 680C91 include:

2 Citations: Showing 1 - 2
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  1. Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites.
    Authors: Breda Et al.
    Proc.Natl.Acad.Sci.U.S.A. 2016;113:5435
  2. A TDO2-AhR Signaling Axis Facilitates Anoikis Resistance and Metastasis in Triple-Negative Breast Cancer.
    Authors: D'Amato Et al.
    Cancer Res 2015;75:4651

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