A 1210477

Catalog # Availability Size / Price Qty
6409/5
6409/25
Cat.No. 6409 - A 1210477 | C46H55N7O7S | CAS No. 1668553-26-1
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Description: Selective, high affinity Mcl-1 inhibitor; proapoptotic

Chemical Name: 7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid

Purity: ≥98%

Product Details
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Biological Activity

Selective, high affinity Mcl-1 inhibitor (Ki = 454 pM). Disrupts Mcl-BIM complexes (IC50 in low μM range). Also inhibits Mcl-1NOXA interactions. Exhibits no effect on Bcl-XL-Bim or Bcl-X-BCL-Xs interactions. Induces apoptosis in multiple myeloma and non-small cell lung cancer cell lines and exhibits a synergistic effect with NavitoclaxTM to induce apoptosis in vitro. Cell permeable.

Technical Data

M.Wt:
850.04
Formula:
C46H55N7O7S
Solubility:
Soluble to 2 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1668553-26-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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