Catalog Number: 4483
Chemical Name: 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
Biological Activity
Inhibitor of eukaryotic elongation factor-2 (eEF-2) kinase (IC50 = 0.28 μM in enzymatic assay). Reduces eEF-2 phosphorylation with little effect on cancer cell growth.
Technical Data
  • M.Wt:
    289.29
  • Formula:
    C13H15N5O3
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    142557-61-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of eukaryotic elongation factor-2 (eEF2): a cautionary note on the anticancer mechanism of an eEF2 kinase inhibitor.
    Chen
    J.Biol.Chem., 2011;286:43951

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