Catalog Number: 4341
Chemical Name: Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole
Biological Activity
Selective α7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3).
Technical Data
  • M.Wt:
    280.37
  • Formula:
    C17H20N4
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    848591-90-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain
    Anderson et al.
    J.Pharmacol.Exp.Ther., 2008;324:179

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