7 nAChR partial agonist; exhibits high affinity for both rat and human α
7 receptors (Ki
values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α
7 over 5-HT3
= 150 nM for 5-HT3
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All Tocris products are intended for laboratory research use only.
[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain
Anderson et al.