The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA
R&D Systems | Catalog # RDC0282
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Nicotinic Acetylcholine R alpha 7/CHRNA7
Long Name
Nicotinic Acetylcholine Receptor alpha 7
Alternate Names
CHRNA7, CHRNA7-2, Nicotinic Acetylcholine Ra 7
Gene Symbol
CHRNA7
UniProt
Additional Nicotinic Acetylcholine R alpha 7/CHRNA7 Products
Product Documents for Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA
Product Specific Notices for Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA
For research use only
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