Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA

Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: Nicotinic Acetylcholine R alpha 7/CHRNA7

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. nAChR alpha 7/CHRNA7 forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once nAChR alpha 7/CHRNA7 binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Related Research Areas

• Neurotransmitter Receptors
• Neurotransmitter Receptors in Blood Pressure Regulation
• Neurotransmitter Receptors on Endothelial Cells
• Neurotransmitter Receptors on VSMC
• Neurotransmitter Receptors, Transporters, and Ion Channels
• Platelet GPCRs
• The Cholinergic System in Alzheimer's Disease