Catalog Number: 1052
Chemical Name: N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Biological Activity
Potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L). Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
    390.29
  • Formula:
    C14H19N3O3S.HBr
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
    107756-30-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype.
    Knepper et al.
    J.Pharmacol.Exp.Ther., 1995;274:97
  2. Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes.
    Luo et al.
    Acta.Pharmacol.Sin., 2007;28:968
  3. Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist.
    Meyer et al.
    J.Med.Chem., 1996;39:4116
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 61603 hydrobromide include:

10 Citations: Showing 1 - 10
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  1. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
    Authors: Montgomery
    Plos One 2017;12:e0168409
  2. Divergent regulation of ER and kiss genes by 17�-estradiol in hypothalamic ARC versus AVPV models.
    Authors: Treen Et al.
    Mol.Endocrinol. 2016;30:217
  3. The α-1A Adrenergic Receptor in the Rabbit Heart.
    Authors: Thomas Et al.
    Nephrol Dial Transplant 2016;11:e0155238
  4. Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
    Authors: Copik Et al.
    PLoS One 2015;10:e0115701
  5. Renalase in hypertension and kidney disease.
    Authors: Desir and Peixoto
    Circ Res 2014;29:42604
  6. A molecular MRI probe to detect treatment of cardiac apoptosis in vivo.
    Authors: Dash Et al.
    Magn Reson Med 2011;66:1152
  7. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
    Authors: Jensen Et al.
    Naunyn Schmiedebergs Arch Pharmacol 2010;382:475
  8. The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries.
    Authors: Jensen Et al.
    PLoS One 2009;54:1137
  9. Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.
    Authors: O-Uchi Et al.
    PLoS One 2008;102:1378
  10. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.
    Authors: Rokosh and Simpson
    Proc Natl Acad Sci U S A 2002;99:9474

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