A 61603 hydrobromide

Catalog # Availability Size / Price Qty
1052/10
1052/50
A 61603 hydrobromide | CAS No. 107756-30-9 | Adrenergic alpha-1 Receptor Agonists
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Description: α1A agonist

Chemical Name: N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide

Product Details
Citations (12)
Supplemental Products
Reviews (1)

Biological Activity

Potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L). Also available as part of the α1-Adrenoceptor Tocriset™.

Technical Data

M.Wt:
390.29
Formula:
C14H19N3O3S.HBr
Solubility:
Soluble to 50 mM in water
Storage:
Desiccate at +4°C
CAS No:
107756-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for A 61603 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for A 61603 hydrobromide include:

12 Citations: Showing 1 - 10

  1. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice.
    Authors: Montgomery
    Plos One  2017;12:e0168409
  2. Divergent regulation of ER and kiss genes by 17�-OE in hypothalamic ARC versus AVPV models.
    Authors: Treen Et al.
    Mol.Endocrinol.  2016;30:217
  3. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
    Authors: Thomas Et al.
    JACC Basic Transl Sci  2016;1:155
  4. The α-1A Adrenergic Receptor in the Rabbit Heart.
    Authors: Thomas Et al.
    Nephrol Dial Transplant  2016;11:e0155238
  5. Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
    Authors: Copik Et al.
    PLoS One  2015;10:e0115701
  6. Renalase in hypertension and kidney disease.
    Authors: Desir and Peixoto
    Circ Res  2014;29:42604
  7. p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.
    Authors: Amirak Et al.
    Biochem J  2013;450:351
  8. A molecular MRI probe to detect treatment of cardiac apoptosis in vivo.
    Authors: Dash Et al.
    Magn Reson Med  2011;66:1152
  9. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
    Authors: Jensen Et al.
    Naunyn Schmiedebergs Arch Pharmacol  2010;382:475
  10. The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries.
    Authors: Jensen Et al.
    PLoS One  2009;54:1137

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A61603 works well on H9C2
By Anonymous on 08/20/2018
Species: Rat

A61603 was used to treat H9C2 for 24hours, works well as intended.


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