A 61603 hydrobromide

  ( 12 citations )    
Product Datasheet
Catalog Number:1052
Chemical Name:N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Product Details
Citations (12)
Supplemental Products
Reviews
Biological Activity
Potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L). Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
    390.29
  • Formula:
    C14H19N3O3S.HBr
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
    107756-30-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 61603 hydrobromide include:

12 Citations: Showing 1 - 10
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  1. An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice.
    Authors: Montgomery
    Plos One  2017;12:e0168409
  2. Divergent regulation of ER and kiss genes by 17�-estradiol in hypothalamic ARC versus AVPV models.
    Authors: Treen Et al.
    Mol.Endocrinol.  2016;30:217
  3. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart.
    Authors: Thomas Et al.
    JACC Basic Transl Sci  2016;1:155
  4. The α-1A Adrenergic Receptor in the Rabbit Heart.
    Authors: Thomas Et al.
    Nephrol Dial Transplant  2016;11:e0155238
  5. Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.
    Authors: Copik Et al.
    PLoS One  2015;10:e0115701
  6. Renalase in hypertension and kidney disease.
    Authors: Desir and Peixoto
    Circ Res  2014;29:42604
  7. p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.
    Authors: Amirak Et al.
    Biochem J  2013;450:351
  8. A molecular MRI probe to detect treatment of cardiac apoptosis in vivo.
    Authors: Dash Et al.
    Magn Reson Med  2011;66:1152
  9. Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.
    Authors: Jensen Et al.
    Naunyn Schmiedebergs Arch Pharmacol  2010;382:475
  10. The α-1D Is the predominant α-1-adrenergic receptor subtype in human epicardial coronary arteries.
    Authors: Jensen Et al.
    PLoS One  2009;54:1137
  11. Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel.
    Authors: O-Uchi Et al.
    PLoS One  2008;102:1378
  12. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.
    Authors: Rokosh and Simpson
    Proc Natl Acad Sci U S A  2002;99:9474
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