Catalog Number: 1052
Chemical Name: N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Biological Activity
Potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L). Also available as part of the α1-Adrenoceptor Tocriset™.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype.
    Knepper et al.
    J.Pharmacol.Exp.Ther., 1995;274:97
  2. Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes.
    Luo et al.
    Acta.Pharmacol.Sin., 2007;28:968
  3. Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist.
    Meyer et al.
    J.Med.Chem., 1996;39:4116
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