A-71623

Tocris Bioscience | Catalog # 2411

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Citations (14)

Product Documents

Potent and selective CCK1 agonist; suppresses feeding

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective CCK1 agonist; suppresses feeding

View all CCK1 Receptor Agonists »

Product Description

A-71623 is a potent CCK₁ agonist (IC₅₀ = 3.7 nM) with 1200-fold selectivity over the CCK₂ receptor. Suppresses food intake following central or peripheral administration.

Product Specifications for A-71623

Molecular Weight

840.97

Formula

C₄₄H₅₆N₈O₉

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

130408-77-4

PubChem ID

121964

InChI Key

KNHCBYMGWWTGSO-ZYADHFCISA-N

SMILES

O=C(N[C@H]([C@](N[C@@H](CC(O)=O)C(N(C)[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O)CCCCNC(NC4=CC=CC=C4C)=O)[C@@H](NC(OC(C)(C)C)=O)CC1=CNC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in 20mM PBS buffer

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

DeNinno Development of CCK-tetrapeptide analogues as potent and selective CCK-A receptor agonists. J.Med.Chem.
Lin Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. Mol.Pharmacol.
Asin A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol.Biochem.Behav. 1992 PMID: 1513850

Product Documents for A-71623

Certificate of Analysis

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Product Specific Notices for A-71623

For research use only

Citations for A-71623

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