Positive allosteric modulator of α
7 nAChRs (IC50
values are 0.98 and 1.12 μ
M for human and rat α
7 receptor ACh-evoked currents respectively, in X. laevis
oocytes). Displays no activity at 5-HT3A
4 or α
2 nAChRs. Brain penetrant.
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In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting
Malysz et al.
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Faghih et al.