A 867744

Key Product Details

Product Description

A 867744 is a positive allosteric modulator of α7 nAChRs (IC₅₀ values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT_3A, α3β4 or α4β2 nAChRs. Brain penetrant.

Product Specifications for A 867744

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for A 867744

The following data is based on the product molecular weight 402.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.41 mL	24.82 mL
5 mM	0.50 mL	2.48 mL	4.96 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Faghih Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor. J.Med.Chem. 2009 PMID: 19419141
• Malysz In vitro pharmacological characterization of a novel allosteric modulator of α 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting J.Pharmacol.Exp.Ther. 2009 PMID: 19389923

Product Documents for A 867744