A 867744

Catalog # Availability Size / Price Qty
4571/10
4571/50
Cat.No. 4571 - A 867744 | C20H19ClN2O3S | CAS No. 1000279-69-5
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Description: Positive allosteric modulator of α7 nAChR

Chemical Name: 4-[5-(4-Chlorophenyl)-2-methyl-3-(1-oxopropyl)-1H-pyrrol-1-yl]benzenesulfonamide

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Biological Activity

Positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. laevis oocytes). Displays no activity at 5-HT3A, α3β4 or α4β2 nAChRs. Brain penetrant.

Technical Data

Formula:
C20H19ClN2O3S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1000279-69-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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