Chemical Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Biological ActivityA 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen.
Ben-David et al.
Cell Stem Cell, 2013;12:167
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
Xin et al.
Citation for A 939572
The citations listed below are publications that use Tocris products. Selected citations for A 939572 include:
1 Citation: Showing 1 - 1
Low glycaemic diets alter lipid metabolism to influence tumour growth
Authors: Lien Et al.
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