Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Biological ActivitySelective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats.
McGaraughty et al.
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Chen et al.
Citations for A 967079
The citations listed below are publications that use Tocris products. Selected citations for A 967079 include:
2 Citations: Showing 1 - 2
Structure of the TRPA1 ion channel suggests regulatory mechanisms.
Authors: Paulsen Et al.
Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
Authors: Ganley Et al.
Mol Brain 2015;35:7626
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Reviews for A 967079
Average Rating: 5 (Based on 1 Review)
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A967079 was used in the animal behavior test to block the TRPA1-mediated chronic itch at the concentration of 10mg/Kg
It may be a little difficult to dissolve the drug at a higher concentration.