A 967079

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4716
Chemical Name:(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Product Details
Citations (2)
Reviews
Biological Activity
Selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.
Technical Data
  • M.Wt:
    207.24
  • Formula:
    C12H14FNO
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1170613-55-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for A 967079 include:

2 Citations: Showing 1 - 2
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  1. Structure of the TRPA1 ion channel suggests regulatory mechanisms.
    Authors: Paulsen Et al.
    Nature  2015;520:511
  2. Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets.
    Authors: Ganley Et al.
    Mol Brain  2015;35:7626

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Average Rating: 5 (Based on 1 review)

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  Mouse Jing Feng 01/04/2018
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Summary

Species Mouse
Pub Med ID 29081531

Other Experimental Details

Other Experimental Details It may be a little difficult to dissolve the drug at a higher concentration.

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