A 967079

Catalog # Availability Size / Price Qty
4716/10
4716/50
TRPA1 Blockers Small Molecule
1 Image
Description: Selective TRPA1 channel blocker

Chemical Name: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime

Purity: ≥98%

Product Details
Citations (2)
Reviews (1)

Biological Activity

Selective TRPA1 channel blocker (IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively). Displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. Exhibits analgesic effects in a rat osteoarthritic pain model.

Technical Data

M.Wt:
207.24
Formula:
C12H14FNO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1170613-55-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for A 967079

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2 Citations: Showing 1 - 2

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Blocking TRPA1 function in chronic itch
By Jing Feng on 01/04/2018
Species: Mouse

A967079 was used in the animal behavior test to block the TRPA1-mediated chronic itch at the concentration of 10mg/Kg

PMID: 29081531

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