A 971432

   
Product Datasheet
Catalog Number:5766
Chemical Name:1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
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Biological Activity
Potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.
Technical Data
  • M.Wt:
    366.24
  • Formula:
    C18H17Cl2NO3
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in 1eq. HCl
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    1240308-45-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Mouse S1P5/EDG-8 (NP_444420) VersaClone cDNA

RDC0465
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Human S1P5/EDG-8 (NP_110387) VersaClone cDNA

RDC0056
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