A 971432

Catalog # Availability Size / Price Qty
5766/10
5766/50
Cat.No. 5766 - A 971432 | C18H17Cl2NO3 | CAS No. 1240308-45-5
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Description: Potent and selective S1P5 agonist

Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥99%

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Biological Activity

Potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Technical Data

M.Wt:
366.24
Formula:
C18H17Cl2NO3
Solubility:
Soluble to 100 mM in 1eq. NaOH and to 100 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at RT
CAS No:
1240308-45-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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