Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
Biological ActivityA 971432 is a potent and selective S1P5 agonist (EC50 values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P1, and >1,600-fold selectivity over S1P2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Citation for A 971432
The citations listed below are publications that use Tocris products. Selected citations for A 971432 include:
1 Citation: Showing 1 - 1
Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Authors: Matsushima-Nishiwaki Et al.
PLoS One 2018;13:e0209050
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