Catalog Number: 5097
Chemical Name: 4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione
Biological Activity
Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.
    Freschauf et al.
    Cancer Res., 2009;69:7739
  2. Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.
    Freschauf et al.
    J.Biol.Chem., 2010;285:2351
  3. DNA end processing by polynucleotide kinase/phosphatase.
    Schellenberg et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:20855
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