Catalog Number: 1297
Alternate Names: Abnormal-cannabidiol
Chemical Name: 4-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
Biological Activity
Neurobehaviorally inactive cannabinoid that acts as a selective agonist for GPR55 (EC50 values are 2.5, >30 and >30 μM at GPR55, CB1 and CB2 receptors respectively). Increases phosphorylation of protein kinases in, and migration of, human umbilical vein endothelial cells.
Technical Data
  • M.Wt:
    314.47
  • Formula:
    C21H30O2
  • Solubility:
    Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)
  • Purity:
    >97%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    22972-55-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The orphan receptor GPR55 is a novel cannabinoid receptor.
    Ryberg et al.
    Br.J.Pharmacol., 2007;152:1092
  2. Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery.
    Ho and Hiley
    Br.J.Pharmacol., 2003;138:1320
  3. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
    Jarai et al.
    Proc.Natl.Acad.Sci.U.S.A., 1999;96:14136
  4. Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1.
    Mo et al.
    Eur.J.Pharmacol., 2004;489:21
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Abn-CBD include:

3 Citations: Showing 1 - 3
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  1. Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis.
    Authors: Hao Et al.
    Cell Death Dis 2015;21:38
  2. Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy.
    Authors: Yang Et al.
    Free Radic Biol Med 2014;68:260
  3. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression.
    Authors: Esposito Et al.
    Br J Pharmacol 2007;151:1272
Tocris Small Molecules
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